UNI-FOLD is a sensitive profile-profile protein fold recognition method. The algorithm outputs a set of alignments between the input (query) sequence and the sequences from the PDB90 database. The PDB90 database consists of representative amino acid sequences obtained by clustering the sequences of known tertiary structure at 90% sequence identity. The alignments reported by UNI-FOLD are ordered by the alignment score significance (p-value).


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Poleksic,A. (2009) Island method for estimating the statistical significance of profile-profile alignment scores, BMC Bioinformatics, 10(1):112.